Round of 16
5/02
5/10
4
5		 (16) Caracas (VEN)  2x2 Santos
(1) Santos (BRA)  3x2 Caracas
(Santos wins, 5-4)
 5/03
5/10
2
3		 (14) Paraná (BRA)  1x2 Libertad
(3) Libertad (PAR)  1x1 Paraná
(Libertad wins, 3-2)
5/02
5/08
4
2		 (9) América (MEX)  3x0 Colo Colo
(8) Colo Colo (CHI)  2x1 América
(América wins, 4-2)
 5/02
5/09
4
3		 (11) Boca Juniors (ARG)  3x0 Vélez Sarsfield
(6) Vélez Sarsfield (ARG)  3x1 Boca Juniors
(Boca Juniors wins, 4-3)
5/03
5/10
4
2		 (12) Nacional (URU)  3x2 Necaxa
(5) Necaxa (MEX)  0x1 Nacional
(Nacional wins, 4-2)
 5/02
5/09
1
2		 (10) São Paulo (BRA)  1x0 Grêmio
(7) Grêmio (BRA)  2x0 São Paulo
(Grêmio wins, 2-1)
5/03
5/08
5
3		 (13) Cúcuta (COL)  5x1 Toluca
(4) Toluca (MEX)  2x0 Cúcuta
(Cúcuta wins, 5-3)
 5/02
5/09
3
2		 (15) Defensor (URU)  3x0 Flamengo
(2) Flamengo (BRA)  2x0 Defensor
(Defensor wins, 3-2)
América, Boca Juniors, Cúcuta, Defensor, Grêmio, Libertad, Nacional and Santos advance